Virus susceptibility and clinical effectiveness of anti-influenza drugs during the 2010–2011 influenza season in Russia

Highlights • Influenza viruses from the 2010–2011 epidemic season were found to be susceptible to oseltamivir and umifenovir. • Umifenovir was found to be effective against oseltamivir-resistant influenza viruses in cell culture-based assays. • Oseltamivir and umifenovir were found to be effective a...

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Veröffentlicht in:	International journal of infectious diseases 2016-02, Vol.43 (C), p.77-84
Hauptverfasser:	Leneva, I.A, Burtseva, E.I, Yatsyshina, S.B, Fedyakina, I.T, Kirillova, E.S, Selkova, E.P, Osipova, E, Maleev, V.V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antiviral Agents - therapeutic use Cell Line Dogs Enzyme Inhibitors - therapeutic use Female Humans Indoles - therapeutic use Infectious Disease Influenza Influenza A Virus, H1N1 Subtype - drug effects Influenza, Human - drug therapy Influenza, Human - virology Male Mice Mice, Inbred BALB C Middle Aged Neuraminidase - antagonists & inhibitors Observational study Oseltamivir Oseltamivir - therapeutic use Pulmonary/Respiratory Retrospective Studies Russia Susceptibility to antivirals Treatment Outcome Umifenovir Young Adult
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Zusammenfassung:	Highlights • Influenza viruses from the 2010–2011 epidemic season were found to be susceptible to oseltamivir and umifenovir. • Umifenovir was found to be effective against oseltamivir-resistant influenza viruses in cell culture-based assays. • Oseltamivir and umifenovir were found to be effective against infection caused by the pandemic A(H1N1)pdm09 virus in mice. • Oseltamivir and umifenovir treatment decreased the duration of symptoms in hospitalized influenza-infected patients.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2016.01.001