Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Previously, a broadly neutralizing antibody, 3I14, active against groups 1 and 2 influenza A viruses was isolated from human memory B cells and showed protection in mice from lethal viral challenge. Here, Harshbarger and Deming et al. provide the crystal structure of 3I14 Fab in complex with H3, H6,...

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Veröffentlicht in:Nature communications 2021-01, Vol.12 (1), p.1-13
Hauptverfasser: Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, Wayne A. Marasco
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Sprache:eng
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Zusammenfassung:Previously, a broadly neutralizing antibody, 3I14, active against groups 1 and 2 influenza A viruses was isolated from human memory B cells and showed protection in mice from lethal viral challenge. Here, Harshbarger and Deming et al. provide the crystal structure of 3I14 Fab in complex with H3, H6, and H10.
ISSN:2041-1723
DOI:10.1038/s41467-020-20879-6