Evaluation of fibrinolytic and antioxidant effects of Allium elburzense bulb extracts

is an endemic plant of the family Amaryllidaceae that grows wild in northern Iran with some nutritional and medicinal applications. The present study was aimed to investigate the fibrinolytic and antioxidant effects of bulb extracts. Hydroalcoholic, aqueous, chloroformic and butanolic extracts were evaluated in this research. antioxidant assays were performed using total phenolic, DPPH, and FRAP methods. In the analysis, animals received i.p. injection of hydroalcoholic extract for 21 days and hydroperoxides level, FRAP value, PT and aPTT were determined in serum samples. The fibrinolytic activity of different extracts was quantitatively evaluated by measurement of clot weight. antioxidant assay showed that aqueous extract had the highest DPPH scavenging and the highest total antioxidant capacity. In the assay, hydroalcoholic extract reduced serum hydroperoxides level and increased serum total antioxidant capacity in rats. fibrinolytic assay revealed remarkable thrombolytic activity for this plant with the highest effect for the aqueous extract. However, coagulation parameters including PT and aPTT were not affected by administration of hydroalcoholic extract in rats. In conclusion, the results of this study revealed the potential antioxidant and fibrinolytic effects of bulb extracts. For developing novel thrombolytic agents, further investigations for isolation of bioactive constituents and finding the underlying mechanisms are suggested.