Interferon-β 1a and SARS Coronavirus Replication

Interferon-β 1a and SARS Coronavirus Replication

A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort...

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Veröffentlicht in:Emerging infectious diseases 2004-02, Vol.10 (2), p.317-319
Hauptverfasser: Hensley, Lisa E, Fritz, Elizabeth A, Jahrling, Peter B, Karp, Christopher L, Huggins, John W, Geisbert, Thomas W
Format: Artikel
Sprache:eng
Schlagworte:
coronavirus
interferon
SARS
therapy
treatment
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Zusammenfassung:A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon (IFN)-β 1a potently inhibits SARS coronavirus replication in vitro.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1002.030482