Association of ERCC1 and XPF polymorphisms with pediatric glioma susceptibility

[...]we found that four SNPs had potential functions, namely, three SNPs of ERCC1, which are rs2298881, rs11615, and rs3212986, and one SNP of XPF (rs2276466). [5,6] Variations in some alleles of ERCC1 gene polymorphisms may attenuate the capacity of DNA repair, and these mutations are mainly concentrated in the 3′ UTR while there are several polymorphisms in the coding region of XPF that bring about possible genetic instability. [...]some ERCC1/XPF genes SNPs may have effects on glioma. [...]the chosen SNPs have potential functions. [...]we lack functional experiments and need to understand how SNPs affect gliomas. [...]more attention should be paid to the interactions between environmental and genetic factors. [...]we identified the relationship