Correlation between PAPP-A serum levels in the first trimester of pregnancy with the occurrence of gestational diabetes, a multicenter cohort study

Correlation between PAPP-A serum levels in the first trimester of pregnancy with the occurrence of gestational diabetes, a multicenter cohort study

This study aimed to investigate the association between first-trimester Pregnancy-associated plasma protein A (PAPP-A) levels and subsequent gestational diabetes mellitus (GDM) development. The study was conducted on 5854 pregnant women who attended routine prenatal care. Maternal biomarkers, includ...

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Veröffentlicht in:BMC Pregnancy and Childbirth 2023-12, Vol.23 (1), p.847-847, Article 847
Hauptverfasser: Borna, Sedigheh, Ashrafzadeh, Masoumeh, Ghaemi, Marjan, Eshraghi, Nasim, Hivechi, Nafiseh, Hantoushzadeh, Sedigheh
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Birth weight
Care and treatment
Childbirth
Cohort analysis
Complications and side effects
Diabetes in pregnancy
Diagnosis
Gestational age
Gestational diabetes
Glucose
Health aspects
Hypertension
Medical screening
Methods
Missing data
Patients
Preeclampsia
Pregnancy
Pregnancy associated plasma protein A
Pregnant women
Proteins
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Zusammenfassung:This study aimed to investigate the association between first-trimester Pregnancy-associated plasma protein A (PAPP-A) levels and subsequent gestational diabetes mellitus (GDM) development. The study was conducted on 5854 pregnant women who attended routine prenatal care. Maternal biomarkers, including PAPP-A and free beta hCG, were measured for all women in a referral laboratory and converted to MoM values. Pregnant women were divided into two groups, based on the serum concentration of PAPP-A, (PAPP-A > 0.4 (normal) and PAPP-A 
ISSN:1471-2393
1471-2393
DOI:10.1186/s12884-023-06155-7