Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease

Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after...

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Veröffentlicht in:	Emerging infectious diseases 2020-02, Vol.26 (2), p.298-306
Hauptverfasser:	Nguyet, Lam Anh, Thanh, Tran Tan, Nhan, Le Nguyen Thanh, Hong, Nguyen Thi Thu, Nhu, Le Nguyen Truc, Van, Hoang Minh Tu, Ny, Nguyen Thi Han, Anh, Nguyen To, Han, Do Duong Kim, Tuan, Ha Manh, Huy, Vu Quang, Viet, Ho Lu, Cuong, Hoang Quoc, Thao, Nguyen Thi Thanh, Viet, Do Chau, Khanh, Truong Huu, Thwaites, Louise, Clapham, Hannah, Hung, Nguyen Thanh, Chau, Nguyen Van Vinh, Thwaites, Guy, Ha, Do Quang, van Doorn, H Rogier, Tan, Le Van
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing - immunology Ataxia Care and treatment Child Child, Preschool coxsackievirus Coxsackievirus infections Diseases Enrollments enterovirus Enterovirus - immunology enterovirus A71 and neutralization Epidemics Female Fever Foot and mouth disease hand Hand, Foot and Mouth Disease - blood Hand, Foot and Mouth Disease - epidemiology Hand, Foot and Mouth Disease - prevention & control Hand, Foot and Mouth Disease - virology Health aspects Hospitals Humans Illnesses Infant Infant, Newborn Infection Infections Male Medical research Nervous system Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease Pathogenic microorganisms Pathogens Patients Plasma Vaccines Variance analysis Vietnam - epidemiology Viral Vaccines viruses
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Beschreibung
Zusammenfassung:	Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after the onset of illness from HFMD patients infected with enterovirus A71 (EV-A71), coxsackievirus A (CVA) 6, CVA10, and CVA16 to study cross neutralization. For homotypic viruses, seropositivity increased from
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2602.190721