An integrative pan‐cancer analysis of the molecular and biological features of glycosyltransferases

Dear Editor, Glycosyltransferases (GTs) played important roles in cancer development and progression.1,2 Here, we conducted a pan-cancer analysis of GTs (Supporting information Table S1)3 based on the TCGA data, CCLE data, single-cell RNA sequencing datasets and our proteogenomic resource, aiming to characterize the molecular features, biological functions and clinical implications of GTs across cancer types. SEE PDF] Widespread gene expression changes of GTs in tumors were observed (Figure 2A, Supporting information Figures S4, S5A and Table S4), among them, three GTs displayed consistent expression alterations in 16 cancer types, including upregulation of ALG3, and downregulation of B3GALT2 and ST6GALNAC3 (Figure 2B). According to our proteogenomic resource of LIHC (CHCC-HBV),10 GTs that contributed to different prognosis of patients were further analyzed.