BASICS OF ANTIOXIDANT THERAPY IN ACUTE PANCREATITIS (EXPERIMENTAL STUDY)

BASICS OF ANTIOXIDANT THERAPY IN ACUTE PANCREATITIS (EXPERIMENTAL STUDY)

The activation of membrane lipid peroxidation, circulatory and tissue hypoxia are crucial triggers for membrane destroying events in acute pancreatitis. The use of anti-oxidant therapy in acute experimental pancreatitis reduces the intensity of lipid peroxidation (the level of diethenoid conjugates...

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Veröffentlicht in:Vestnik anesteziologii i reanimatologii 2018-01, Vol.13 (3), p.14-18
Hauptverfasser: Vlasov, A.P., Mitroshin, A.N., Nikolskiy, V.I., Suslov, A.V., Muratova, T.A.
Format: Artikel
Sprache:eng
Schlagworte:
antioxidant
hypoxia
lipid peroxidation
microcirculation
pancreatitis
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Zusammenfassung:The activation of membrane lipid peroxidation, circulatory and tissue hypoxia are crucial triggers for membrane destroying events in acute pancreatitis. The use of anti-oxidant therapy in acute experimental pancreatitis reduces the intensity of lipid peroxidation (the level of diethenoid conjugates statistically confidently reduces by 30.4-32.5%) and restores the tissue respiration (oxidation-reduction potential is above the control one by 10-15%). Such therapy provides less effect on the microcirculation.
ISSN:2078-5658
2078-5658
2541-8653
DOI:10.21292/2078-5658-2016-13-3-14-18