An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis

To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph II...

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Veröffentlicht in:	Scientific reports 2021-05, Vol.11 (1), p.11111-7, Article 11111
Hauptverfasser:	Szalai, Eszter, Szucs, Gabriella, Szamosi, Szilvia, Aszalos, Zsuzsa, Afra, Ildiko, Kemeny-Beke, Adam
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4023 692/4023/1670 692/4023/1671 Aged Case-Control Studies Cell Count Cornea - metabolism Corneal Keratocytes - metabolism Cross-Sectional Studies Female Humanities and Social Sciences Humans Male Microscopy, Confocal Middle Aged multidisciplinary Science Science (multidisciplinary) Scleroderma, Systemic - metabolism
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Zusammenfassung:	To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph III, Heidelberg Engineering GmbH, Heidelberg, Germany) and ocular surface evaluation. Subbasal nerve plexus morphology was investigated using automated software analysis (ACCMetrics V3; University of Manchester, Manchester, UK). Keratocyte cell densities in the anterior stroma were significantly lower in patients with SSc compared to controls (P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-90594-9