Disentangling the potential roles of the human gut mycobiome and metabolites in asthma

HC and NT group exhibited distinct fungal–metabolite connections, whereas the networks in ICS group were markedly low (Fig. 4), suggesting complex relationships among bacteria, fungi, and metabolites. [...]the ICS treatment altered bacterial–metabolite and fungal–metabolite connections. SEE PDF] Our study was limited by its relatively small-sample size, a lack of corrections for multiple testing and racially diverse participants, and an independent replication cohort. [...]asthma patients harboured altered gut fungal compositions, metabolic profiles, and associated metabolic pathways.