Recent Advances of Degradation Technologies Based on PROTAC Mechanism

Recent Advances of Degradation Technologies Based on PROTAC Mechanism

PROTAC (proteolysis-targeting chimeras), which selectively degrades target proteins, has become the most popular technology for drug development in recent years. Here, we introduce the history of PROTAC, and summarize the recent advances in novel types of degradation technologies based on the PROTAC...

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Veröffentlicht in:Biomolecules (Basel, Switzerland) Switzerland), 2022-09, Vol.12 (9), p.1257
Hauptverfasser: Xiao, Mingchao, Zhao, Jiaojiao, Wang, Qiang, Liu, Jia, Ma, Leina
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Binding sites
Biomolecules
Chimeras
Degradation
Drug development
Drug discovery
Drug resistance
E3 ligase
Forecasts and trends
Health aspects
Kinases
Ligands
Medical research
Methods
Pharmaceutical research
Phosphatase
Phosphorylation
Photodegradation
protein degradation technology
protein of interest
Proteins
Proteolysis
proteolysis-targeting chimeras
Review
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Beschreibung
Zusammenfassung:PROTAC (proteolysis-targeting chimeras), which selectively degrades target proteins, has become the most popular technology for drug development in recent years. Here, we introduce the history of PROTAC, and summarize the recent advances in novel types of degradation technologies based on the PROTAC mechanism, including TF-PROTAC, Light-controllable PROTAC, PhosphoTAC, LYTAC, AUTAC, ATTEC, CMA, RNA-PROTAC and RIBOTACs. In addition, the clinical progress, current challenges and future prospects of degradation technologies based on PROTAC mechanism are discussed.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12091257