Clinical observations of giant cell hepatitis in children

Giant cell hepatitis is characterized, by inflammation and large multinucleated. hepatocytes in hepatic parenchyma It is an unusual hepatocytes response to various noxious stimuli, characterized, by presence of multinucleated cells in liver with generally dismal clinical outcome. Giant cell hepatitis is commonly reported, in neonatal and. infantile liver diseases but rarely in adults (postinfantile giant cell hepatitis). Giant cell hepatitis is associated, with many diseases, including drugs toxicity, viral and. autoimmune liver diseases, with autoimmune hepatitis being the most prevalent. We report some clinical cases of giant cell hepatitis with review of literature regarding various etiological agents and their respective prognostic outcome.