Antimicrobial drugs and community-acquired Clostridium difficile-associated disease, UK

In a population-based case-control study of community acquired Clostridium difficile-associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not...

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Veröffentlicht in:	Emerging infectious diseases 2007-05, Vol.13 (5), p.761-763
Hauptverfasser:	Delaney, J A Chris, Dial, Sandra, Barkun, Alan, Suissa, Samy
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Anti-infective agents antimicrobial agents Case-Control Studies Clostridioides difficile - drug effects Clostridium Clostridium difficile–associated disease Clostridium Infections - drug therapy Clostridium Infections - epidemiology Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Databases, Factual Dispatch Drug Resistance, Multiple, Bacterial - drug effects epidemiology fluoroquinolones Health aspects Humans Infection Infection control Medical research Medicine, Experimental risk factors United Kingdom - epidemiology
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Zusammenfassung:	In a population-based case-control study of community acquired Clostridium difficile-associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CDAD after 6 months.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1305.061124