Synthesis, crystal structure, and anti-breast cancer activity of a novel metal-porphyrinic complex [YK(TCPP)(OH)2·(solvents)x]

A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of...

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Veröffentlicht in:	Brazilian journal of medical and biological research 2018-01, Vol.51 (1), p.e6858-e6858
Hauptverfasser:	Liu, J-C, Gu, J-J, Zhang, Y-S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology BIOLOGY Biosynthesis Breast cancer Breast cancer cell Breast Neoplasms - drug therapy Cell Line, Tumor Coordination Complexes - chemistry Coordination Complexes - pharmacology Crystal structure Crystallography, X-Ray Formazans Heterometallic Humans Hydrogen Bonding MEDICINE, RESEARCH & EXPERIMENTAL Metal-Organic Frameworks - chemistry Metal-Organic Frameworks - pharmacology Molecular Structure Porphyrins - chemistry Porphyrins - pharmacology Reference Values Reproducibility of Results Single crystal Tetrazolium Salts
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Zusammenfassung:	A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, in vitro anticancer activity of complex 1 on three human breast cancer cells (BT474, SKBr-3 and ZR-75-30) was further determined.
ISSN:	0100-879X 1414-431X 1414-431X
DOI:	10.1590/1414-431X20176858