The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.

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Veröffentlicht in:Chimia 2003-10, Vol.57 (10), p.601
Hauptverfasser: Chaperon, André, Bertschy, Hugo, Franz-Schrumpf, Anne-Laurence, Hugelet, Bertrand, Neels, Antonia, Stoeckli-Evans, Helen, Neier, Reinhard
Format: Artikel
Sprache:eng
Schlagworte:
Biomimetic synthesis
Mukaiyama aldol reaction
Porphobilinogen
Silyl enol ether
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Zusammenfassung:The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.
ISSN:0009-4293
2673-2424
DOI:10.2533/000942903777678812