APPLICATIONS OF PHARMACOGENETIC TESTING FOR PERSONALIZATION OF THERAPY WITH ORAL ANTICOAGULANTS IN RUSSIA

APPLICATIONS OF PHARMACOGENETIC TESTING FOR PERSONALIZATION OF THERAPY WITH ORAL ANTICOAGULANTS IN RUSSIA

The clinical significance of the patient genetic characteristics in the individual pharmacological response to oral anticoagulants is considered. Possible tactics of warfarin dosing and new oral anticoagulants choice on the basis of pharmacogenetic testing as well as indications for this approach in...

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Veröffentlicht in:Rat͡s︡ionalʹnai͡a︡ farmakoterapii͡a︡ v kardiologii 2013-01, Vol.9 (5), p.525-531
Hauptverfasser: Sychev, D. A., Kazakov, R. E., Otdelenov, V. A., Prokofiev, A. B.
Format: Artikel
Sprache:eng
Schlagworte:
anticoagulants
ces1
cyp2c9
dabigatran
new oral anticoagulants
pharmacogenetics
vkorc1
warfarin
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Zusammenfassung:The clinical significance of the patient genetic characteristics in the individual pharmacological response to oral anticoagulants is considered. Possible tactics of warfarin dosing and new oral anticoagulants choice on the basis of pharmacogenetic testing as well as indications for this approach in clinical practice are discussed. It should increase efficacy and safety of anticoagulant therapy.
ISSN:1819-6446
2225-3653
DOI:10.20996/1819-6446-2013-9-5-525-531