Aggravating effect of abnormal low-density protein cholesterol level on coronary atherosclerotic plaque in type 2 diabetes mellitus patients assessed by coronary computed tomography angiography

The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggravating effect of abnormal LDL-C levels on coronary artery plaques assessed by coronary compu...

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Veröffentlicht in:	Cardiovascular Diabetology 2024-07, Vol.23 (1), p.234-13, Article 234
Hauptverfasser:	Jiang, Yi-Ning, Gao, Yue, Zhang, Yu-Shan, Min, Chen-Yan, Shen, Li-Ting, Yan, Wei-Feng, Yang, Zhi-Gang, Shi, Rui, Li, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiography Arteriosclerosis Atherosclerosis Atherosclerotic Biomarkers - blood Blood cholesterol Calcification Calcification (ectopic) Cardiovascular disease Cardiovascular diseases Cholesterol Cholesterol, LDL - blood Comorbidity Comparative analysis Computed tomography Computed Tomography Angiography Coronary Angiography Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary artery plaque Coronary computed tomography angiography Coronary vessels Coronary Vessels - diagnostic imaging Cross-Sectional Studies CT imaging Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - epidemiology Female Health risks High density lipoprotein Humans Low density lipoprotein Low density lipoproteins Low-density lipoprotein cholesterol Male Medical imaging Medical research Medicine, Experimental Metabolic disorders Middle Aged Patients Plaque, Atherosclerotic Plaques Predictive Value of Tests Prognosis Regression analysis Retrospective Studies Risk Assessment Risk Factors Severity of Illness Index Stenosis Tomography Type 2 diabetes Type 2 diabetes mellitus Vascular Calcification - blood Vascular Calcification - diagnostic imaging Vascular Calcification - epidemiology
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Zusammenfassung:	The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggravating effect of abnormal LDL-C levels on coronary artery plaques assessed by coronary computed tomography angiography (CCTA) in T2DM. This study collected 3439 T2DM patients from September 2011 to February 2022. Comparative analysis of differences in coronary plaque characteristics was performed for the patients between the normal LDL-C level group and the abnormal LDL-C level group. Factors with P
ISSN:	1475-2840 1475-2840
DOI:	10.1186/s12933-024-02304-0