PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy

PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy

Aim. To investigate the correlation between PPP1R12A gene copy number and clinical outcomes of oxaliplatin-based regimen in stage III colorectal cancer (CRC). Methods. A total of 139 paraffin-embedded tissue samples of stage III CRC patients who received oxaliplatin-based treatment after radical sur...

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Veröffentlicht in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.928-934-188
Hauptverfasser: Li, Jianwen, Yin, Lu, Lin, Moubin, Wei, Qing, Peng, Kangsheng, Li, Huaguang, Li, Ajian, Zhang, Chenbo, Liu, Zhanju
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Apoptosis
Cancer
Cancer therapies
Chemotherapy
Clinical outcomes
Colorectal cancer
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Deoxyribonucleic acid
DNA
Drug therapy
Female
Gene Dosage
Genetic aspects
Genetic code
Hospitals
Humans
Male
Medical prognosis
Medicine
Middle Aged
Mortality
Myosin-Light-Chain Phosphatase - genetics
Neoplasm Recurrence, Local
Neoplasm Staging
Observations
Organoplatinum Compounds - therapeutic use
Phosphatase
Proteins
Surgery
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Zusammenfassung:Aim. To investigate the correlation between PPP1R12A gene copy number and clinical outcomes of oxaliplatin-based regimen in stage III colorectal cancer (CRC). Methods. A total of 139 paraffin-embedded tissue samples of stage III CRC patients who received oxaliplatin-based treatment after radical surgery were recruited. Genomic DNA was extracted and purified from paraffin-embedded sections. Quantitative PCR methods were used to detect the relative copy number (RCN) of PPP1R12A. Results. Statistical analysis demonstrated that low PPP1R12A RCN was associated with poor RFS (HR=2.186, 95% CI: 1.293–3.696; P=0.003) and OS (HR=2.782, 95% CI: 1.531–5.052; P
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/417184