Aromatic C-H addition of ketones to imines enabled by manganese catalysis
Selectivity control of varied C–H bonds in a complex molecule is a long-standing goal and still a great challenge in C–H activation field. Most often, such selectivity is achieved by the innate reactivity of different C–H bonds. In this context, the classic Mannich reaction of acetophenone derivativ...
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Veröffentlicht in: | Nature communications 2017-10, Vol.8 (1), p.1169-9, Article 1169 |
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Sprache: | eng |
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Zusammenfassung: | Selectivity control of varied C–H bonds in a complex molecule is a long-standing goal and still a great challenge in C–H activation field. Most often, such selectivity is achieved by the innate reactivity of different C–H bonds. In this context, the classic Mannich reaction of acetophenone derivatives and imines is ascribed to the more reactive C(sp
3
)–H bonds α to the carbonyl, with the much less reactive aromatic C(sp
2
)–H bonds remaining intact. Herein we report an aromatic C(sp
2
)–H addition of ketones to imines enabled by manganese catalysis, which totally reverses the innate reactivity of C–H bonds α to the carbonyl and those on the aromatic ring. Diverse products of
ortho
-C–H aminoalkylated ketones, cyclized
exo
-olefinic isoindolines, and three-component methylated isoindolines can be successfully accessed under mild reaction conditions, which significantly expands the synthetic utilities of ketones as simple bulk chemicals.
The Mannich reaction proceeds by functionalization of C(sp
3
)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable
o
-aminoalkylacetophenones and isoindolines via C(sp
2
)-H functionalization with imines. |
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ISSN: | 2041-1723 2041-1723 |
DOI: | 10.1038/s41467-017-01262-4 |