Association between resting heart rate and low natural killer cell activity: a cross-sectional study

Resting heart rate (RHR), a simple physiological indicator, has been demonstrated to be associated with inflammation and even metabolic disorders. This study aimed to investigate whether RHR is associated with natural killer cell activity (NKA) in a large population of healthy adults using a novel a...

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Veröffentlicht in:	Frontiers in immunology 2024-09, Vol.15, p.1465953
Hauptverfasser:	Oh, Hyoju, Cho, A-Ra, Jeon, Joo-Hwan, Suh, Eunkyung, Moon, Junhyung, Cho, Baek Hwan, Lee, Yun-Kyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged cortisol Cross-Sectional Studies Female Heart Rate Humans immunity Interferon-gamma - blood Interferon-gamma - metabolism Killer Cells, Natural - immunology Male Middle Aged natural killer cell natural killer cell activity Rest - physiology RESTING HEART RATE Young Adult
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Zusammenfassung:	Resting heart rate (RHR), a simple physiological indicator, has been demonstrated to be associated with inflammation and even metabolic disorders. This study aimed to investigate whether RHR is associated with natural killer cell activity (NKA) in a large population of healthy adults using a novel assay to measure NKA. This cross-sectional study included 7,500 subjects in the final analysis. NKA was estimated by measuring the amount of interferon-gamma (IFN-γ) released by activated natural killer cells; low NKA was defined as IFN-γ level
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2024.1465953