Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis

Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis

To evaluate quadrant and sector retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in relapsing–remitting multiple sclerosis (RR-MS) patients. Optical coherence tomography measures of RNFL and TMV were studied in 321 eyes without prior optic neuritis (ON) (MS unaffected), 151...

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Veröffentlicht in:eNeurologicalSci 2015-06, Vol.1 (2), p.30-37
Hauptverfasser: Loughran-Fjeldstad, Anette S., Carlson, Noel G., Husebye, Cassandra D., Cook, Lawrence J., Rose, John W.
Format: Artikel
Sprache:eng
Schlagworte:
Axonal loss
Multiple sclerosis
Optic neuritis
Optical coherence tomography
Original
Retinal nerve fiber layer
Total macular volume
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Zusammenfassung:To evaluate quadrant and sector retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in relapsing–remitting multiple sclerosis (RR-MS) patients. Optical coherence tomography measures of RNFL and TMV were studied in 321 eyes without prior optic neuritis (ON) (MS unaffected), 151 eyes with prior ON (MS affected), and 148 healthy control eyes. Mean RNFL thickness was significantly lower in the MS affected and MS unaffected groups relative to the control group (p
ISSN:2405-6502
2405-6502
DOI:10.1016/j.ensci.2015.09.004