The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vi...

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Veröffentlicht in:	Cell death & disease 2021-07, Vol.12 (8), p.734-734, Article 734
Hauptverfasser:	Ning, Li, Rui, Xiong, Bo, Wang, Qing, Geng
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436 631/45/173 Acetylation Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Chromatin remodeling Circadian rhythms Fibrosis Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - chemistry Histone Deacetylases - metabolism Humans Immunology Inflammation Ischemia Life Sciences Models, Biological Neurodegeneration Organ Specificity Physiology Review Review Article Transcription Wounds and Injuries - enzymology
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Beschreibung
Zusammenfassung:	Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.
ISSN:	2041-4889 2041-4889
DOI:	10.1038/s41419-021-04019-6