Semisynthesis of Taxol®: An improved procedure for the isolation of 10-deacetylbaccatin III
From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) can be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-Dcan be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure co...
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| Veröffentlicht in: | Journal of the Serbian Chemical Society 1999, Vol.64 (9), p.497-503 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III
(10-DAB) can be isolated in quantities of up to 297 mg per kg of fresh
needles. Additional quantities of 10-Dcan be obtained from the extract by
NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step
procedure converts 10-Dinto taxol in 58% overall yield.
nema |
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| ISSN: | 0352-5139 1820-7421 |
| DOI: | 10.2298/JSC9909497S |