Super-sentinel chickens and detection of low-pathogenicity influenza virus

Chicken interferon-alpha administered perorally in drinking water acts on the oropharyngeal mucosal system as an adjuvant that causes chickens to rapidly seroconvert after natural infection by low-pathogenicity Influenza virus. These chickens, termed super sentinels, can serve as sensitive early det...

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Veröffentlicht in:	Emerging infectious diseases 2007-10, Vol.13 (10), p.1608-1610
Hauptverfasser:	Marcus, Philip I, Girshick, Theodore, van der Heide, Louis, Sekellick, Margaret J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Administration, Oral Animals avian influenza chicken interferon Chickens - immunology Chickens - virology Detectors Dispatch Drinking water Health aspects Immunocompromised Host Immunological adjuvants Influenza Influenza A Virus, H7N7 Subtype - immunology Influenza in Birds - diagnosis Influenza in Birds - epidemiology Influenza in Birds - immunology Influenza virus Interferon Interferon Type I - administration & dosage peroral adjuvant Poultry industry Recombinant Proteins sentinel chickens Sentinel Surveillance - veterinary Seroepidemiologic Studies
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Beschreibung
Zusammenfassung:	Chicken interferon-alpha administered perorally in drinking water acts on the oropharyngeal mucosal system as an adjuvant that causes chickens to rapidly seroconvert after natural infection by low-pathogenicity Influenza virus. These chickens, termed super sentinels, can serve as sensitive early detectors of clinically inapparent infections.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1310.061552