In-situ Gelling System: A Promising Delivery Method for Treating Periodontitis

Background: Periodontitis is a chronic and potentially severe inflammatory disease that can affect both men and women. It is caused by various factors such as inadequate oral health, stress, consumption of alcoholic beverages, cigarette smoking, food, some immunity-related diseases, and chronic diseases. If left untreated, these disorders can ultimately contribute to missing teeth and other mouth diseases. Various delivery systems like fibers, stripes, films, and microparticulate systems are available to treat periodontitis. In-situ drug delivery systems use stimuli-sensitive polymers that undergo a solution-to-gel phase transition, which enables them to cover the entire pocket. As a result, they are more effective in treating periodontitis than other delivery systems. Aim: Provide an overview of periodontitis, its therapies, and how an in-situ gelling system can treat it effectively and safely. Methods: To achieve this aim, an extensive systematic search was done in different databases, including Science Direct, Springer, PubMed, ResearchGate, and Google Scholar, so manyof the relatedpriorresearchwerereviewed. Conclusion: In-situ gelling systems are encouraging drug delivery systems for treating periodontitis. because of their ability to deliver drugs at the site of infection while decreasing the possibility of side effects. These systems containing biocompatible, biodegradable, and water-soluble polymers have promising results in improving the treatment of periodontitis.