New Piperazine Derivatives Synthesized from Thio‐Substituted Polyhalogeno‐2‐nitro‐1,3‐butadienes

It is known that polyhalogeno‐nitro‐1,3‐butadienes are important starting materials for the synthesis of polyfunctionalized bioactive heterocycles. Novel N,S ‐substituted nitrobutadienes ( 4a-j ) were synthesized from the reaction of the monothio‐substituted nitrodiene derivatives ( 2a ) and ( 2b ) with some piperazine derivatives. These new compounds are stable and the structures of these products were characterized by spectroscopic data. The structure of the novel N,S ‐substituted nitrodiene compound ( 4g ) synthesized in this study was also elucidated by single crystal x‐ray analysis.