Alleviation of DSS-induced colitis via bovine colostrum-derived extracellular vesicles with microRNA let-7a-5p is mediated by regulating Akkermansia and β -hydroxybutyrate in gut environments

Alleviation of DSS-induced colitis via bovine colostrum-derived extracellular vesicles with microRNA let-7a-5p is mediated by regulating Akkermansia and β -hydroxybutyrate in gut environments

Even though studying on the possible involvement of extracellular vesicles (EVs) in host-microbe interactions, how these relationships mediate host physiology has not clarified yet. Our current findings provide insights into the encouraging benefits of dietary source-derived EVs and microRNAs (miRNA...

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Veröffentlicht in:Microbiology spectrum 2023-12, Vol.11 (6), p.e0012123-e0012123
Hauptverfasser: Mun, Daye, Kang, Minkyoung, Shin, Minhye, Choi, Hye Jin, Kang, An Na, Ryu, Sangdon, Unno, Tatsuya, Maburutse, Brighton E, Oh, Sangnam, Kim, Younghoon
Format: Artikel
Sprache:eng
Schlagworte:
3-Hydroxybutyric Acid
Akkermansia
Animals
Applied and Industrial Microbiology
bovine colostrum
bta-let-7a-5p
Cattle
Colitis - chemically induced
Colostrum
Extracellular Vesicles
Female
Humans
metabolome
microbiome
MicroRNAs - genetics
Pregnancy
Research Article
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Zusammenfassung:Even though studying on the possible involvement of extracellular vesicles (EVs) in host-microbe interactions, how these relationships mediate host physiology has not clarified yet. Our current findings provide insights into the encouraging benefits of dietary source-derived EVs and microRNAs (miRNAs) on organic acid production and ultimately stimulating gut microbiome for human health, suggesting that supplementation of dietary colostrum EVs and miRNAs is a novel preventive strategy for the treatment of inflammatory bowel disease.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.00121-23