Low expression of transferrin receptor 2 predict poor prognosis in gastric cancer patients

Low expression of transferrin receptor 2 predict poor prognosis in gastric cancer patients

This study was to detect the expression level of transferrin receptor 2 (TfR2) in gastric cancer and to analyze its value in predicting the prognosis of gastric cancer patients. Real‐time PCR (RT‐qPCR) was applied to detect the mRNA expression of TfR2 in gastric cancer tissues and paired adjacent no...

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Veröffentlicht in:The Kaohsiung journal of medical sciences 2020-12, Vol.36 (12), p.1014-1020
Hauptverfasser: Zhao, Qian‐Fu, Ji, Jun, Cai, Qu, Wang, Chao, Shi, Min, Zhou, Chen‐Fei, Zhu, Zheng‐Gang, Zhang, Jun
Format: Artikel
Sprache:eng
Schlagworte:
Breast cancer
Cytoplasm
Gastric cancer
Infrared imaging systems
Iron
Medical prognosis
Metabolism
Metastasis
Polymerase chain reaction
prognosis
Protein expression
Proteins
Software
Survival analysis
TfR2
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Zusammenfassung:This study was to detect the expression level of transferrin receptor 2 (TfR2) in gastric cancer and to analyze its value in predicting the prognosis of gastric cancer patients. Real‐time PCR (RT‐qPCR) was applied to detect the mRNA expression of TfR2 in gastric cancer tissues and paired adjacent nontumorous tissues. Immunohistochemistry (IHC) and western blotting were used to determine the protein expression of TfR2 in gastric cancer, and the relationship with the prognosis of gastric cancer patients was analyzed. The results were: (1) The mRNA and protein levels of TfR2 in gastric cancer tissues were remarkably lower than those in adjacent nontumorous gastric tissue (P 
ISSN:1607-551X
2410-8650
DOI:10.1002/kjm2.12278