Amplified parabrachial nucleus activity in a rat model of trigeminal neuropathic pain

Amplified parabrachial nucleus activity in a rat model of trigeminal neuropathic pain

Highlights • Chronic constriction injury (CCI) of the infraorbital nerve in rats results in profound pain (CCI-Pain). • Parabrachial neurons in animals with CCI-Pain exhibit abnormal, prolonged after-discharges. • Some parabrachial neurons in CCI-Pain animals show a different type of amplified activ...

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Veröffentlicht in:Neurobiology of pain 2018-01, Vol.3, p.22-30
Hauptverfasser: Uddin, Olivia, Studlack, Paige, Akintola, Titilola, Raver, Charles, Castro, Alberto, Masri, Radi, Keller, Asaf
Format: Artikel
Sprache:eng
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Pain Medicine
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Zusammenfassung:Highlights • Chronic constriction injury (CCI) of the infraorbital nerve in rats results in profound pain (CCI-Pain). • Parabrachial neurons in animals with CCI-Pain exhibit abnormal, prolonged after-discharges. • Some parabrachial neurons in CCI-Pain animals show a different type of amplified activity – post-inhibitory rebound spikes in response to a sensory stimulus.
ISSN:2452-073X
2452-073X
DOI:10.1016/j.ynpai.2018.02.002