Phytochemical Identification, Acute, and Sub-Acute Oral Toxicity Studies of the Foliar Extract of Withania frutescens

( ) is a medicinal plant widely used to treat several diseases. This work aims to study phytochemical composition as well as acute and subacute toxicity of hydroethanolic extract in mice. The phytochemical composition of extract was performed using gas chromatographic analysis. Acute toxicity was st...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2020-10, Vol.25 (19), p.4528
Hauptverfasser: El Moussaoui, Abdelfattah, Bourhia, Mohammed, Jawhari, Fatima Zahra, Mechchate, Hamza, Slighoua, Meryem, Bari, Ahmed, Ullah, Riaz, Mahmood, Hafiz Majid, Ali, Syed Saeed, Ibenmoussa, Samir, Bousta, Dalila, Bari, Amina
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:( ) is a medicinal plant widely used to treat several diseases. This work aims to study phytochemical composition as well as acute and subacute toxicity of hydroethanolic extract in mice. The phytochemical composition of extract was performed using gas chromatographic analysis. Acute toxicity was studied in vivo with oral administration of single doses 400 mg/kg, 1000 mg/kg, and 2000 mg/kg for 14 days. Subacute toxicity was studied with the administration of repeated doses of 400 mg/kg/day and 2000 mg/kg/day for 28 days. Phytochemical analysis of hydro-ethanolic extract confirmed the presence of interesting chemical compounds. Acute toxicity results showed no toxic symptoms in mice treated with an increasing dose up to a maximum of 2000 mg/kg. Alongside acute toxicity, subacute data showed no clinical symptoms nor biochemical or histological alteration in mice treated with an increasing dose up to a maximum of 2000 mg/kg compared to the control group ( < 0.05). This study shows no toxic effects in animals treated with extract, and, therefore, this plant can be considered safe in animals up to 2000 mg/kg under both acute and subacute toxicity conditions.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25194528