Azithromycin failure in Mycoplasma genitalium urethritis

Azithromycin failure in Mycoplasma genitalium urethritis

We report significant failure rates (28%, 95% confidence interval 15%-45%) after administering 1 g azithromycin to men with Mycoplasma genitalium-positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted...

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Veröffentlicht in:Emerging infectious diseases 2006-07, Vol.12 (7), p.1149-1152
Hauptverfasser: Bradshaw, Catriona S, Jensen, Jorgen S, Tabrizi, Sepehr N, Read, Timothy R H, Garland, Suzanne M, Hopkins, Carol A, Moss, Lorna M, Fairley, Christopher K
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Anti-Bacterial Agents - therapeutic use
Australia
Aza Compounds - therapeutic use
azithromycin
Azithromycin - therapeutic use
Diagnosis
Dispatch
Female
Fluoroquinolones
Humans
Male
Middle Aged
Moxifloxacin
Mycoplasma genitalium
Mycoplasma genitalium - isolation & purification
Mycoplasma Infections - drug therapy
Mycoplasma Infections - microbiology
non-gonococcal urethritis
Prognosis
Quinolines - therapeutic use
Treatment Failure
Urethritis
Urethritis - drug therapy
Urethritis - microbiology
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Zusammenfassung:We report significant failure rates (28%, 95% confidence interval 15%-45%) after administering 1 g azithromycin to men with Mycoplasma genitalium-positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all cases. These findings have implications for management of urethritis.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1207.051558