Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H 2 O 2 → ‧OH for tumoral therapy. Unfortunately, H 2 O 2 is often taken from the limited endogenous supply of H 2 O 2 in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H 2 O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe 3+ -N ≡ C-Fe 2+ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O 2 , H 2 O 2, and ‧OH from H 2 O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments. Chemodynamic therapy (CDT) uses Fenton chemistry to covert hydrogen peroxide in cancer cells to toxic hydroxyl radicals, but endogenous hydrogen peroxide is insufficient to drive sustainable CDT. Here, the authors report a water oxidation CoFe Prussian blue nanoframe to provide sustained, external energy free self-supply of hydroxyl radicals for CDT.