An essential role for MEF2C in the cortical response to loss of sleep in mice

Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency and amplitude, and a characteristic rebound and resolution of...

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Veröffentlicht in:eLife 2020-08, Vol.9
Hauptverfasser: Bjorness, Theresa E, Kulkarni, Ashwinikumar, Rybalchenko, Volodymyr, Suzuki, Ayako, Bridges, Catherine, Harrington, Adam J, Cowan, Christopher W, Takahashi, Joseph S, Konopka, Genevieve, Greene, Robert W
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Sprache:eng
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Zusammenfassung:Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency and amplitude, and a characteristic rebound and resolution of slow wave sleep-slow wave activity (SWS-SWA). However, the molecular mechanism(s) mediating the sleep-loss response are not well understood. We show that sleep-loss regulates MEF2C phosphorylation, a key mechanism regulating MEF2C transcriptional activity, and that MEF2C function in postnatal excitatory forebrain neurons is required for the biological events in response to sleep loss in C57BL/6J mice. These include altered gene expression, the increase and recovery of synaptic strength, and the rebound and resolution of SWS-SWA, which implicate MEF2C as an essential regulator of sleep function.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.58331