Dairy-derived peptides for satiety

[Display omitted] •Casein peptides appear to predominantly target GLP-1, CCK secretion and DPP-IV.•Whey peptides appear to influence CCK, serotonin and ghrelin pathways.•Certain Dairy peptides that stimulate satiety signaling in vitro can reduce food intake in vivo. Satiety hormones produced in the gastrointestinal tract are key players in influencing appetite and food intake. Dairy proteins that target these gastric signals have the potential to make one feel ‘fuller for longer’. While effects of whey and casein on appetite and food intake are well documented, this review focuses on individual dairy peptides. The evidence of these peptide bioactives on satiety signaling in vitro using cellular models and in vivo via intervention trials is summarized. Dairy protein hydrolysates are also reviewed for their satiating properties. How their efficacy compares to other notable food derived peptides and how this efficacy can be lost, bolstered or protected during gut transit is also summarized.