Pregnancy Before Completion of Follow-Up in Gestational Trophoblastic Neoplasia: a Case Report

Introduction: Choriocarcinoma is a rare and malignant tumor, which may present during or following any type of pregnancy. This tumor often demonstrates rapid hematogenous spread to multiple organs and is associated with high levels of human chorionic gonadotropin (HCG) and a good response to chemotherapy. Herein, we introduced a case of metastatic choriocarcinoma who failed to response to conventional therapies. Case presentation: A 22-year-old woman referred with vaginal bleeding. The evaluations revealed that she had a metastatic choriocarcinoma that failed to response to conventional therapies. Continuation of chemotherapy was not possible due to the development of neutropenia. Interestingly, the patient achieved a complete remission spontaneously without receiving further treatment. During the follow-up period, when the patient should not become pregnant, she became pregnant and had no problems during the pregnancy. Conclusions: Gestational trophoblastic neoplasia is a rare disease. The majority of women suffering from this disease can be cured and their reproductive function could be preserved through the utilization of sensitive quantitation assay for human chorionic gonadotropin (β-hCG) and highly effective chemotherapy.