Macrolide-resistant Bordetella pertussis infection in newborn girl, France

A macrolide antimicrobial drug was administered to a newborn with cough. On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA sequencing and PCR-restriction fragment length polymorphism showed a 2047 A-to-G mutation in the 3 copies of...

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Veröffentlicht in:	Emerging infectious diseases 2012-06, Vol.18 (6), p.966-968
Hauptverfasser:	Guillot, Sophie, Descours, Ghislaine, Gillet, Yves, Etienne, Jérome, Floret, Daniel, Guiso, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibacterial agents antibacterial drugs antimicrobial resistance Azithromycin - pharmacology Azithromycin - therapeutic use bacteria Bordetella pertussis Bordetella pertussis - drug effects Bordetella pertussis - genetics Care and treatment Clarithromycin - pharmacology Clarithromycin - therapeutic use Disease transmission Dispatch DNA Mutational Analysis DNA sequencing Drug resistance Drug resistance in microorganisms Drug Resistance, Bacterial Erythromycin Exchange Transfusion, Whole Blood Female Genes Health aspects Humans Infant, Newborn Media coverage Nucleotide sequencing respiratory infections RNA RNA, Ribosomal, 23S - genetics Treatment Outcome whooping cough Whooping Cough - diagnosis Whooping Cough - therapy
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Zusammenfassung:	A macrolide antimicrobial drug was administered to a newborn with cough. On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA sequencing and PCR-restriction fragment length polymorphism showed a 2047 A-to-G mutation in the 3 copies of the 23S rRNA gene. Monitoring for macrolide resistance is essential in infants
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1806.120091