P5.25: Diurnal Variation of Cardio-Ankle Vascular Index in Individuals with and Without Heart Disease

Background Clinical studies revealed age and pathological-related arterial stiffening. Arterial stiffening is associated with a higher risk of cardiovascular disease. Cardio-ankle vascular index (CAVI), which reflects both central elastic and peripheral muscular arterial stiffness, has been applied as a simple noninvasive method to evaluate the risk for cardiovascular events. However, whether it is necessary to standardize the time of the day when performing this measurement is unknown. We aim to examine the effect of daytime on CAVI in individuals with and without heart disease. Methods We investigated the daytime variation of CAVI using Vasera VS-1500N (Fukuda Denshi; Japan) in 23 healthy young individuals (28.3±4.7yr, HY), 22 healthy elderly individuals (61.1 ±9.0 yr, HE) and 25 patients with heart disease (63.9±11.5yr, HD). Results The effect of time on CAVI was shown to be significant in both univariate and multivariate analysis. Age was found as a significant determinant of CAVI (p