Establishment of an induced pluripotent stem cell line (FDEENTi001-A) from a patient with pathological myopia

Pathological myopia (PM) is a retinal degenerative disease with an increasing prevalence in Asia. The peripheral blood mononuclear cells (PBMCs) from a patient with PM were successfully reprogrammed to induced pluripotent stem cells (iPSCs) using integration-free method, Sendai viral (SeV) vectors e...

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Veröffentlicht in:	Stem cell research 2019-01, Vol.34, p.101369-101369, Article 101369
Hauptverfasser:	Bai, Xinyue, Yang, Xianjie, Cheng, Yun, Chen, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques - methods Cell Line Humans Induced Pluripotent Stem Cells - pathology Male Mice Middle Aged Myopia, Degenerative - pathology
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Zusammenfassung:	Pathological myopia (PM) is a retinal degenerative disease with an increasing prevalence in Asia. The peripheral blood mononuclear cells (PBMCs) from a patient with PM were successfully reprogrammed to induced pluripotent stem cells (iPSCs) using integration-free method, Sendai viral (SeV) vectors expressing OCT4, SOX2, KLF4 and C-MYC. This line may provide a useful resource for exploring the pathogenesis of PM.
ISSN:	1873-5061 1876-7753
DOI:	10.1016/j.scr.2018.101369