Circulating microRNAs as novel biomarkers for heart failure

We Sought to identify circulating miRNAs suitable for HF diagnosis. In this study, a genome-wide plasma miRNA microarray was performed in 13 HF patients and 3 controls. The expression levels of selected differentially expressed, upregulated miRNAs (miR-3135b, miR-3908 and miR-5571-5p) were validated...

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Veröffentlicht in:	Hellenic journal of cardiology 2018-07, Vol.59 (4), p.209-214
Hauptverfasser:	Chen, Feng, Yang, Jiefu, Li, Yingying, Wang, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged biomarkers Biomarkers - blood Case-Control Studies Circulating MicroRNA - blood Female Gene Expression Profiling heart failure Heart Failure - blood Heart Failure - diagnosis Humans Male Middle Aged miRNAs Real-Time Polymerase Chain Reaction ROC Curve
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Zusammenfassung:	We Sought to identify circulating miRNAs suitable for HF diagnosis. In this study, a genome-wide plasma miRNA microarray was performed in 13 HF patients and 3 controls. The expression levels of selected differentially expressed, upregulated miRNAs (miR-3135b, miR-3908 and miR-5571-5p) were validated with quantitative real-time PCR (qRT-PCR) assays in an independent cohort of 33 HF patients and 20 controls. Of all the miRNAs analyzed, miR-3135b (P
ISSN:	1109-9666 2241-5955
DOI:	10.1016/j.hjc.2017.10.002