Biotechnical toxicity assessment system of rare earth metals compounds

Introduction. Expanding the scope of application of rare-earth metal compounds that are unique in their properties increases the interest of many researchers in studying the impact of rare-earth metals and their compounds on human health and the environment. One of the most relevant and modern methods for assessing the safety of the studied media for a biological test object is bioassay. Problem Statement. The objective necessity of determining the combined effect of rare earth metals and their compounds on human health and the environment involves the use of biological systems. Modern methods of bioassay are extremely sensitive, which is sufficient to determine sub-threshold concentrations of hazardous substances in accordance with international standards. Thus, the use of these methods can make it possible to determine the index and the degree of toxicity of rare earth metal compounds with high accuracy in order to prepare a package of necessary documentation on industrial safety of products. Theoretical Part. Based on the studied toxicological effects of rare earth metals, the authors proposed to conduct a toxicity assessment based on the concept of biotechnical systems. The object of research was oxides and carbonates of rare earth metals. The results of the study to determine the index and the degree of toxicity of rare earth metal compounds, as well as to assess the lethal concentration of LC50 (24 h) by biotesting using test organisms Paramecium Caudatum were used to write a safety data sheet for cerium oxide and carbonate. Conclusion. The studies have shown that a certain modification of the technical solutions embedded in the devices of the Biotester series makes it possible to correctly solve the problem of assessing the toxicity of rare earth metals and their compounds. Based on the research results, the safety data sheets were developed.