Outpatient parenteral antibiotic therapy in a renal transplant population : a single-center experience
Outpatient parenteral antimicrobial therapy (OPAT) is a well-established method in medical specialties. Its use in renal transplant recipients has not been thoroughly explored. No guidelines within this patient subset exist. This study describes OPAT outcomes within a UK teaching hospital renal tran...
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Veröffentlicht in: | Saudi journal of kidney diseases and transplantation 2015-11, Vol.26 (6), p.1121-1129 |
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Sprache: | eng |
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Zusammenfassung: | Outpatient parenteral antimicrobial therapy (OPAT) is a well-established method in
medical specialties. Its use in renal transplant recipients has not been thoroughly explored. No
guidelines within this patient subset exist. This study describes OPAT outcomes within a UK
teaching hospital renal transplant population. Renal function, mapped by estimated glomerular
filtration rate (eGFR), and clinical response to infection were collected retrospectively. A total of
635 antimicrobial episodes were administered to nine renal transplant patients over 12 discrete
OPAT courses during the study period. Eleven of 12 OPAT courses (91.67 %) produced a clinical
improvement in infection. One course was terminated due to immunosuppressive-related
neutropenia. No patient required admission due to failure of OPAT or adverse events. There was no
significant change in graft function throughout the OPAT courses compared with baseline renal
function (ANOVA, P = 0.06). One minor line infection was reported. This was treated conservatively
and did not interrupt the OPAT. OPAT is safe and clinically effective in our renal
transplant recipients with no significant deterioration in eGFR. The incidence of adverse events,
specifically line complications, was lower in our population than those reported in the literature.
Future work should develop OPAT guidelines designed for transplant recipients to outline the
degree of monitoring required. |
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ISSN: | 1319-2442 2320-3838 |
DOI: | 10.4103/1319-2442.168560 |