Alterations in spontaneous brain activity of maintenance hemodialysis patients with restless legs syndrome: a cross-sectional case-control study

Through resting state functional magnetic resonance imaging (rs-fMRI) we evaluate the spontaneous brain activity changes of maintenance hemodialysis (MHD) patients with restless legs syndrome (RSL) and analyzed the imaging features and related mechanisms of RLS in patients with MHD. We select 27 MHD patients with RLS and 27 patients without RSL matched by age, gender, cognitive function. Both groups underwent neuropsychological tests and MRI scans. MRI data analysis was performed to obtain and compare the amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and regional homogeneity (ReHo) values, which were mALFF, mfALFF, and mReHo. Clinical data were collected and compared. Differentiated indicators and RLS scores conduct Pearson correlation analysis. Compared with the MHD-nRLS group, the MHD-RLS group showed significantly lower mALFF values in the left precentral, right precentral gyrus, and right postcentral gyrus, lower mfALFF values in the left precentral gyrus, right precentral gyrus, left calcarine fissure, left lingual gyrus, left postcentral gyrus, and right postcentral gyrus, and lower mReHo values in the left precentral gyrus, right precentral gyrus, left calcarine fissure, left lingual gyrus, left postcentral gyrus, and right postcentral gyrus, and right postcentral gyrus (P