$Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states$

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability of NF-κB activation. However, fewer cells respond to shorter pulse intervals (

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Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2016-07, Vol.7 (1), p.12057-12057, Article 12057
Hauptverfasser:	Adamson, Antony, Boddington, Christopher, Downton, Polly, Rowe, William, Bagnall, James, Lam, Connie, Maya-Mendoza, Apolinar, Schmidt, Lorraine, Harper, Claire V., Spiller, David G., Rand, David A., Jackson, Dean A., White, Michael R. H., Paszek, Pawel
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/19 14/34 38/39 42/35 631/250/127 631/250/516/1909 631/553/2712 631/80/86 82/1 Cell Line, Tumor Feedback, Physiological Gene Expression Regulation Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - immunology Humanities and Social Sciences Humans I-kappa B Kinase - genetics I-kappa B Kinase - immunology Interleukin-1beta - pharmacology Luminescent Proteins - genetics Luminescent Proteins - immunology multidisciplinary Neurons NF-kappa B - genetics NF-kappa B - immunology NF-KappaB Inhibitor alpha - genetics NF-KappaB Inhibitor alpha - immunology Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Red Fluorescent Protein RNA, Small Interfering - genetics RNA, Small Interfering - immunology Science Science (multidisciplinary) Signal Transduction - immunology Tumor Necrosis Factor alpha-Induced Protein 3 - antagonists & inhibitors Tumor Necrosis Factor alpha-Induced Protein 3 - genetics Tumor Necrosis Factor alpha-Induced Protein 3 - immunology Tumor Necrosis Factor-alpha - pharmacology
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Beschreibung
Zusammenfassung:	Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability of NF-κB activation. However, fewer cells respond to shorter pulse intervals (
ISSN:	2041-1723 2041-1723
DOI:	10.1038/ncomms12057