Impact of non-canonical ALK fusion on the efficacy of targeted therapy in non-small cell lung cancer

[...]56 patients who received ALK-TKI treatment were enrolled [Supplementary Figure 1, http://links.lww.com/CM9/B791]. [...]most uncommon ALK fusions detected by DNA-based NGS may generate transcripts and proteins, and these cases may respond to ALK-TKIs as those involving canonical fusions do. [...]non-canonical ALK fusion detected by DNA-based NGS was not validated at the RNA or protein level. [...]we provide knowledge of the impact of non-canonical ALK fusion on efficacy based on different generations of ALK-TKIs and whether brain metastasis is present at baseline.