A Novel Whole Yeast-Based Subunit Oral Vaccine Against Eimeria tenella in Chickens

Cheap, easy-to-produce oral vaccines are needed for control of coccidiosis in chickens to reduce the impact of this disease on welfare and economic performance. yeast expressing three antigens were developed and delivered as heat-killed, freeze-dried whole yeast oral vaccines to chickens in four sep...

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Veröffentlicht in:	Frontiers in immunology 2022-02, Vol.13, p.809711-809711
Hauptverfasser:	Soutter, Francesca, Werling, Dirk, Nolan, Matthew, Küster, Tatiana, Attree, Elizabeth, Marugán-Hernández, Virginia, Kim, Sungwon, Tomley, Fiona M, Blake, Damer P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals chicken Chickens - immunology Chickens - parasitology Coccidiosis - prevention & control Coccidiosis - veterinary Eimeria tenella Eimeria tenella - growth & development Eimeria tenella - immunology Female Immunology Male Poultry Diseases - parasitology Poultry Diseases - prevention & control Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Vaccines - genetics Protozoan Vaccines - immunology Saccharomyces cerevisiae Saccharomyces cerevisiae - immunology Vaccination - methods Vaccination - veterinary vaccine Vaccines, Subunit - immunology yeast
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Beschreibung
Zusammenfassung:	Cheap, easy-to-produce oral vaccines are needed for control of coccidiosis in chickens to reduce the impact of this disease on welfare and economic performance. yeast expressing three antigens were developed and delivered as heat-killed, freeze-dried whole yeast oral vaccines to chickens in four separate studies. After vaccination, replication was reduced following low dose challenge (250 oocysts) in Hy-Line Brown layer chickens (p
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2022.809711