Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infe...

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Veröffentlicht in:	Emerging infectious diseases 2022-04, Vol.28 (4), p.828-832
Hauptverfasser:	Laing, Eric D, Weiss, Carol D, Samuels, Emily C, Coggins, Si'Ana A, Wang, Wei, Wang, Richard, Vassell, Russell, Sterling, Spencer L, Tso, Marana S, Conner, Tonia, Goguet, Emilie, Moser, Matthew, Jackson-Thompson, Belinda M, Illinik, Luca, Davies, Julian, Ortega, Orlando, Parmelee, Edward, Hollis-Perry, Monique, Maiolatesi, Santina E, Wang, Gregory, Ramsey, Kathleen F, Reyes, Anatalio E, Alcorta, Yolanda, Wong, Mimi A, Lindrose, Alyssa R, Duplessis, Christopher A, Tribble, David R, Malloy, Allison M W, Burgess, Timothy H, Pollett, Simon D, Olsen, Cara H, Broder, Christopher C, Mitre, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Viral Antibody Formation coronavirus disease Coronaviruses COVID-19 COVID-19 - epidemiology COVID-19 - prevention & control COVID-19 Vaccines Dispatch Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers Health aspects Health care Health Personnel Humans Immune response Immunization Infectious diseases Medical personnel respiratory infections SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Vaccination Viral antibodies viruses
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Beschreibung
Zusammenfassung:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2804.212037