Studies toward synthesis of the core skeleton of spiroaspertrione A

Studies toward synthesis of the core skeleton of spiroaspertrione A

Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp . TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro...

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Veröffentlicht in:Frontiers in chemistry 2022-10, Vol.10, p.1022533-1022533
Hauptverfasser: Shen, Zhong-Hui, Lu, Si-Yuan, Zheng, Jing-Yun, Zhang, Xiang-Zhi, Peng, Jin-Bao, Ma, Ai-Jun
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
core skeleton
natural product
spiroaspertrione A
studies
synthesis
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Zusammenfassung:Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp . TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.1022533