Therapeutic effects of aerial parts of Smyrnium cordifolium ethanolic extract on ethylene glycol-induced kidney calculi in rats

Introduction: In this study, the effects of the ethanolic extract of aerial parts (stem and leaves) of Smyrnium cordifolium (S. cordifolium) Boiss on the ethylene glycol(EG)-induced kidney calculi in rats was investigated. Materials and methods: Thirty-six male Wistar albino rats were randomly divid...

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Veröffentlicht in:Journal of basic research in medical sciences 2018-09, Vol.5 (4), p.14-21
Hauptverfasser: Dovodizadeh, Zohreh, Rouhi, Leila, Azizi, Shahrzad
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Sprache:eng
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Zusammenfassung:Introduction: In this study, the effects of the ethanolic extract of aerial parts (stem and leaves) of Smyrnium cordifolium (S. cordifolium) Boiss on the ethylene glycol(EG)-induced kidney calculi in rats was investigated. Materials and methods: Thirty-six male Wistar albino rats were randomly divided in 6 groups. Group I (normal control), Groups II (control of EG) to VI received EG 1% v/v in water for 28 days. Animals in Groups III and IV (preventive groups) received ethanolic extract of stem and leaves of S. cordifolium in 200 mg/kg and 400 mg/kg orally in water for 28 days, respectively. Groups V and VI (treatment groups) received extract in 200 mg/kg and 400 mg/kg orally in water from 15th to 28th day, respectively. Results: Results showed that the level of urine oxalate, blood urea and creatinine in EG group vs. normal control significantly increased (P
ISSN:2383-0506
2383-0972
DOI:10.29252/jbrms.5.4.14