Multi-Omics Analysis of NFE2L2-Altered TCGA-Cervical Squamous Cell Carcinoma Patients

Genetic alterations in the NFE2L2 gene have been identified across various cancers, and the dysregulation of the NRF2 pathway due to these alterations leads to drug and radioresistance in several cancers. Identification of biomarkers associated with these alterations allows researchers and clinicians to provide personalized medicine and a quicker diagnosis. In this current study, we carried out an integrated, multi-omics, multi-database analysis of exome and transcriptomic data of NFE2L2-altered TCGA-Cervical squamous cell carcinoma (CSCC) patients against wild-type counterparts. Finally, we discovered the genes associated with NFE2L2 alterations and identified the prognostic genes which could be used as potential biomarkers in the NFE2L2-mutated CSCC patients. Our findings might be useful in the early diagnosis of NFE2L2-mutated CSCC patients.